Assay Detail
Functional
CHEMBL5533554
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Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-(N-dithiobenzyl piperazine)-1,8-naphthalimide as a potent multi-target antitumor agent with good efficacy, limited toxicity, and low resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.90 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 7.92 |
| CHEMBL5575221 | — | — | 1 | 5.81 |
| CHEMBL5567591 | — | — | 1 | 5.44 |
| CHEMBL5571947 | — | — | 1 | 5.37 |
| CHEMBL5566298 | — | — | 1 | 5.36 |
| CHEMBL5595686 | — | — | 1 | 5.32 |
| CHEMBL5569440 | — | — | 1 | 5.13 |
| CHEMBL5574843 | — | — | 1 | 5.12 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.10 |
| CHEMBL5573364 | — | — | 1 | 5.01 |
| CHEMBL5571742 | — | — | 1 | 4.94 |
| CHEMBL5572051 | — | — | 1 | 4.93 |
| CHEMBL5575819 | — | — | 1 | 4.84 |
| CHEMBL5590830 | — | — | 1 | 4.82 |
| CHEMBL5564611 | — | — | 1 | 4.77 |
| CHEMBL5565709 | — | — | 1 | 4.76 |
| CHEMBL5563125 | — | — | 1 | 4.67 |
| CHEMBL5570305 | — | — | 1 | 4.65 |
| CHEMBL5574893 | — | — | 1 | 4.65 |
| CHEMBL5564756 | — | — | 1 | 4.63 |
| CHEMBL5569669 | — | — | 1 | 4.62 |
| CHEMBL5565721 | — | — | 1 | 4.60 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.59 |
| CHEMBL5563941 | — | — | 1 | 4.57 |
| CHEMBL5570923 | — | — | 1 | 4.55 |
| CHEMBL5563986 | — | — | 1 | 4.55 |
| CHEMBL5575285 | — | — | 1 | 4.53 |
| CHEMBL5574405 | — | — | 1 | 4.52 |
| CHEMBL5574231 | — | — | 1 | 4.51 |
| CHEMBL5555115 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5575221 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL5567591 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5571947 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL5566298 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL5595686 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL5569440 | — | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL5574843 | — | IC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL5573364 | — | IC50 | = | 9750.0 | nM | 5.01 |
| CHEMBL5571742 | — | IC50 | = | 11380.0 | nM | 4.94 |
| CHEMBL5572051 | — | IC50 | = | 11830.0 | nM | 4.93 |
| CHEMBL5575819 | — | IC50 | = | 14330.0 | nM | 4.84 |
| CHEMBL5590830 | — | IC50 | = | 15320.0 | nM | 4.82 |
| CHEMBL5564611 | — | IC50 | = | 16830.0 | nM | 4.77 |
| CHEMBL5565709 | — | IC50 | = | 17370.0 | nM | 4.76 |
| CHEMBL5563125 | — | IC50 | = | 21470.0 | nM | 4.67 |
| CHEMBL5570305 | — | IC50 | = | 22380.0 | nM | 4.65 |
| CHEMBL5574893 | — | IC50 | = | 22380.0 | nM | 4.65 |
| CHEMBL5564756 | — | IC50 | = | 23210.0 | nM | 4.63 |
| CHEMBL5569669 | — | IC50 | = | 23710.0 | nM | 4.62 |
| CHEMBL5565721 | — | IC50 | = | 25310.0 | nM | 4.60 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 25480.0 | nM | 4.59 |
| CHEMBL5563941 | — | IC50 | = | 26840.0 | nM | 4.57 |
| CHEMBL5570923 | — | IC50 | = | 28410.0 | nM | 4.55 |
| CHEMBL5563986 | — | IC50 | = | 28460.0 | nM | 4.55 |
| CHEMBL5575285 | — | IC50 | = | 29710.0 | nM | 4.53 |
| CHEMBL5574405 | — | IC50 | = | 30480.0 | nM | 4.52 |
| CHEMBL5574231 | — | IC50 | = | 31140.0 | nM | 4.51 |
| CHEMBL5555115 | — | IC50 | = | 31460.0 | nM | 4.50 |
| CHEMBL5574093 | — | IC50 | = | 34370.0 | nM | 4.46 |
| CHEMBL5573458 | — | IC50 | = | 38470.0 | nM | 4.42 |
| CHEMBL5573601 | — | IC50 | = | 39580.0 | nM | 4.40 |
| CHEMBL5568885 | — | IC50 | = | 40610.0 | nM | 4.39 |
| CHEMBL5572721 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5572376 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5570951 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5571223 | — | IC50 | > | 50000.0 | nM | - |