Assay Detail
Functional
CHEMBL5533556
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Antiproliferative activity against human T24 cells incubated for 48 hrs by MTT assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-24 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-(N-dithiobenzyl piperazine)-1,8-naphthalimide as a potent multi-target antitumor agent with good efficacy, limited toxicity, and low resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.92 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5575221 | — | — | 1 | 6.23 |
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 5.96 |
| CHEMBL5595686 | — | — | 1 | 5.68 |
| CHEMBL5567591 | — | — | 1 | 5.52 |
| CHEMBL5571947 | — | — | 1 | 5.43 |
| CHEMBL5569440 | — | — | 1 | 5.41 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.30 |
| CHEMBL5566298 | — | — | 1 | 5.20 |
| CHEMBL5571742 | — | — | 1 | 5.16 |
| CHEMBL5574843 | — | — | 1 | 5.13 |
| CHEMBL5573364 | — | — | 1 | 5.07 |
| CHEMBL5575819 | — | — | 1 | 4.98 |
| CHEMBL5590830 | — | — | 1 | 4.91 |
| CHEMBL5572051 | — | — | 1 | 4.83 |
| CHEMBL5564611 | — | — | 1 | 4.79 |
| CHEMBL5563941 | — | — | 1 | 4.75 |
| CHEMBL5563125 | — | — | 1 | 4.71 |
| CHEMBL5565709 | — | — | 1 | 4.69 |
| CHEMBL5569669 | — | — | 1 | 4.69 |
| CHEMBL5570305 | — | — | 1 | 4.69 |
| CHEMBL5564756 | — | — | 1 | 4.67 |
| CHEMBL5565721 | — | — | 1 | 4.67 |
| CHEMBL5570923 | — | — | 1 | 4.65 |
| CHEMBL5575285 | — | — | 1 | 4.65 |
| CHEMBL5574893 | — | — | 1 | 4.62 |
| CHEMBL5555115 | — | — | 1 | 4.61 |
| CHEMBL5574405 | — | — | 1 | 4.60 |
| CHEMBL5563986 | — | — | 1 | 4.58 |
| CHEMBL5573601 | — | — | 1 | 4.54 |
| CHEMBL5574231 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5575221 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL43482 | MITONAFIDE | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5595686 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL5567591 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL5571947 | — | IC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL5569440 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL5566298 | — | IC50 | = | 6250.0 | nM | 5.20 |
| CHEMBL5571742 | — | IC50 | = | 6910.0 | nM | 5.16 |
| CHEMBL5574843 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL5573364 | — | IC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL5575819 | — | IC50 | = | 10370.0 | nM | 4.98 |
| CHEMBL5590830 | — | IC50 | = | 12410.0 | nM | 4.91 |
| CHEMBL5572051 | — | IC50 | = | 14640.0 | nM | 4.83 |
| CHEMBL5564611 | — | IC50 | = | 16360.0 | nM | 4.79 |
| CHEMBL5563941 | — | IC50 | = | 17730.0 | nM | 4.75 |
| CHEMBL5563125 | — | IC50 | = | 19340.0 | nM | 4.71 |
| CHEMBL5570305 | — | IC50 | = | 20310.0 | nM | 4.69 |
| CHEMBL5565709 | — | IC50 | = | 20440.0 | nM | 4.69 |
| CHEMBL5569669 | — | IC50 | = | 20370.0 | nM | 4.69 |
| CHEMBL5564756 | — | IC50 | = | 21340.0 | nM | 4.67 |
| CHEMBL5565721 | — | IC50 | = | 21130.0 | nM | 4.67 |
| CHEMBL5570923 | — | IC50 | = | 22350.0 | nM | 4.65 |
| CHEMBL5575285 | — | IC50 | = | 22550.0 | nM | 4.65 |
| CHEMBL5574893 | — | IC50 | = | 24050.0 | nM | 4.62 |
| CHEMBL5555115 | — | IC50 | = | 24360.0 | nM | 4.61 |
| CHEMBL5574405 | — | IC50 | = | 25130.0 | nM | 4.60 |
| CHEMBL5563986 | — | IC50 | = | 26460.0 | nM | 4.58 |
| CHEMBL5573601 | — | IC50 | = | 29180.0 | nM | 4.54 |
| CHEMBL5574231 | — | IC50 | = | 31190.0 | nM | 4.51 |
| CHEMBL5568885 | — | IC50 | = | 31710.0 | nM | 4.50 |
| CHEMBL5574093 | — | IC50 | = | 31470.0 | nM | 4.50 |
| CHEMBL5573458 | — | IC50 | = | 32440.0 | nM | 4.49 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 40140.0 | nM | 4.40 |
| CHEMBL5570951 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5571223 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5572376 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5572721 | — | IC50 | > | 50000.0 | nM | - |