Assay Detail

CHEMBL5533748

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Binding

Inhibition of JAK1 (unknown origin)

ChEMBL ↗

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Target

Tyrosine-protein kinase JAK1 (CHEMBL2835) ↗

Open DB target context

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Tyrosine-protein kinase JAK1 (CHEMBL2835) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase JAK1

CHEMBL2835

Anchored from Assay target.

Protein identity Tyrosine-protein kinase JAK1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosine-protein kinase JAK1 (CHEMBL2835) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents.

Waitman KB, de Almeida LC, Primi MC, Carlos JAEG, Ruiz C, Kronenberger T, Laufer S, Goettert MI, Poso A, Vassiliades SV, de Souza VAM, Toledo MFZJ, Hassimotto NMA, Cameron MD, Bannister TD, Costa-Lotufo LV, Machado-Neto JA, Tavares MT, Parise-Filho R.
Eur J Med Chem (2024) 263 : 115935 -115935
PubMed 37989057 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	10.05	10.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1789941	RUXOLITINIB	4.0	1	10.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1789941	RUXOLITINIB	IC50	=	0.09	nM	10.05