Assay Detail

CHEMBL5533752

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Binding

Inhibition of HDAC6 (unknown origin)

ChEMBL ↗

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Target

Histone deacetylase 6 (CHEMBL1865) ↗

Open DB target context

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Histone deacetylase 6 (CHEMBL1865) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Histone deacetylase 6

CHEMBL1865

Anchored from Assay target.

Protein identity Histone deacetylase 6

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Histone deacetylase 6 (CHEMBL1865) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents.

Waitman KB, de Almeida LC, Primi MC, Carlos JAEG, Ruiz C, Kronenberger T, Laufer S, Goettert MI, Poso A, Vassiliades SV, de Souza VAM, Toledo MFZJ, Hassimotto NMA, Cameron MD, Bannister TD, Costa-Lotufo LV, Machado-Neto JA, Tavares MT, Parise-Filho R.
Eur J Med Chem (2024) 263 : 115935 -115935
PubMed 37989057 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	3	7.19	8.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2179618	NEXTURASTAT A	—	1	8.30
CHEMBL98	VORINOSTAT	4.0	1	7.68
CHEMBL408513	BELINOSTAT	4.0	1	5.58

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2179618	NEXTURASTAT A	IC50	=	5.0	nM	8.30
CHEMBL98	VORINOSTAT	IC50	=	21.0	nM	7.68
CHEMBL408513	BELINOSTAT	IC50	=	2600.0	nM	5.58