Assay Detail
Functional
CHEMBL5534339
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Antiproliferative activity against human HeLa cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.95 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297643 | APILIMOD | 2.0 | 1 | 6.85 |
| CHEMBL5568998 | — | — | 1 | 6.37 |
| CHEMBL4126314 | — | — | 1 | 6.00 |
| CHEMBL2032358 | — | — | 1 | 5.91 |
| CHEMBL5572490 | — | — | 1 | 4.64 |
| CHEMBL5590460 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297643 | APILIMOD | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5568998 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4126314 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2032358 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5572490 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5590460 | — | IC50 | > | 5000.0 | nM | - |