Assay Detail
Binding
CHEMBL5534754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MYT1 incubated for 60 mins in presence of tracer178 by HTRF analysis
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.80 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199076 | LUNRESERTIB | 2.0 | 1 | 8.82 |
| CHEMBL5562687 | — | — | 1 | 8.72 |
| CHEMBL5566629 | — | — | 1 | 8.59 |
| CHEMBL5200005 | — | — | 1 | 8.54 |
| CHEMBL5573176 | — | — | 1 | 8.44 |
| CHEMBL5572884 | — | — | 1 | 8.38 |
| CHEMBL5569464 | — | — | 1 | 8.37 |
| CHEMBL5573390 | — | — | 1 | 8.34 |
| CHEMBL5575890 | — | — | 1 | 8.32 |
| CHEMBL5567277 | — | — | 1 | 8.32 |
| CHEMBL5573971 | — | — | 1 | 8.31 |
| CHEMBL5569840 | — | — | 1 | 8.26 |
| CHEMBL5571889 | — | — | 1 | 8.24 |
| CHEMBL5573662 | — | — | 1 | 8.18 |
| CHEMBL5563675 | — | — | 1 | 8.15 |
| CHEMBL5570485 | — | — | 1 | 7.99 |
| CHEMBL5566455 | — | — | 1 | 7.98 |
| CHEMBL5565137 | — | — | 1 | 7.94 |
| CHEMBL5564808 | — | — | 1 | 7.79 |
| CHEMBL5566287 | — | — | 1 | 7.76 |
| CHEMBL5574963 | — | — | 1 | 7.63 |
| CHEMBL5571632 | — | — | 1 | 7.60 |
| CHEMBL5572439 | — | — | 1 | 7.31 |
| CHEMBL5573978 | — | — | 1 | 7.16 |
| CHEMBL5574840 | — | — | 1 | 6.65 |
| CHEMBL5569793 | — | — | 1 | 6.45 |
| CHEMBL5570533 | — | — | 1 | 6.15 |
| CHEMBL5572096 | — | — | 1 | 5.92 |
| CHEMBL5593294 | — | — | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199076 | LUNRESERTIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5562687 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5566629 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5200005 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5573176 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5572884 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5569464 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL5573390 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL5575890 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5567277 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5573971 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL5569840 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL5571889 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL5573662 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL5563675 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL5570485 | — | IC50 | = | 10.3 | nM | 7.99 |
| CHEMBL5566455 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL5565137 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5564808 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL5566287 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL5574963 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL5571632 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL5572439 | — | IC50 | = | 48.9 | nM | 7.31 |
| CHEMBL5573978 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL5574840 | — | IC50 | = | 222.9 | nM | 6.65 |
| CHEMBL5569793 | — | IC50 | = | 359.1 | nM | 6.45 |
| CHEMBL5570533 | — | IC50 | = | 713.8 | nM | 6.15 |
| CHEMBL5572096 | — | IC50 | = | 1213.0 | nM | 5.92 |
| CHEMBL5593294 | — | IC50 | = | 1495.0 | nM | 5.83 |