Assay Detail
Binding
CHEMBL5534756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK1 phosphorylation at Thr14 residue in human HCC1569 cells incubated for 6 hrs by Western blot analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCC1569 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.25 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5199076 | LUNRESERTIB | 2.0 | 1 | 7.28 |
| CHEMBL5562687 | — | — | 1 | 7.20 |
| CHEMBL5566629 | — | — | 1 | 7.04 |
| CHEMBL5573971 | — | — | 1 | 6.57 |
| CHEMBL5573176 | — | — | 1 | 6.57 |
| CHEMBL5567277 | — | — | 1 | 6.54 |
| CHEMBL5573390 | — | — | 1 | 6.53 |
| CHEMBL5569840 | — | — | 1 | 6.48 |
| CHEMBL5563675 | — | — | 1 | 6.45 |
| CHEMBL5572884 | — | — | 1 | 6.38 |
| CHEMBL5575890 | — | — | 1 | 6.24 |
| CHEMBL5571889 | — | — | 1 | 6.18 |
| CHEMBL5565137 | — | — | 1 | 6.15 |
| CHEMBL5571632 | — | — | 1 | 5.81 |
| CHEMBL5570485 | — | — | 1 | 5.72 |
| CHEMBL5564808 | — | — | 1 | 5.46 |
| CHEMBL5574963 | — | — | 1 | 5.44 |
| CHEMBL5569464 | — | — | 1 | 5.44 |
| CHEMBL5566455 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5199076 | LUNRESERTIB | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL5562687 | — | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL5566629 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5573971 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL5573176 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL5567277 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL5573390 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL5569840 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL5563675 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL5572884 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5575890 | — | IC50 | = | 578.0 | nM | 6.24 |
| CHEMBL5571889 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5565137 | — | IC50 | = | 705.0 | nM | 6.15 |
| CHEMBL5571632 | — | IC50 | = | 1541.0 | nM | 5.81 |
| CHEMBL5570485 | — | IC50 | = | 1892.0 | nM | 5.72 |
| CHEMBL5564808 | — | IC50 | = | 3426.0 | nM | 5.46 |
| CHEMBL5574963 | — | IC50 | = | 3628.0 | nM | 5.44 |
| CHEMBL5569464 | — | IC50 | = | 3615.0 | nM | 5.44 |
| CHEMBL5566455 | — | IC50 | = | 5891.0 | nM | 5.23 |