Assay Detail
Binding
CHEMBL5535003
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE4D7 (unknown origin) using FAM-cyclic-3',5'-AMP as substrate incubated for 1 hrs by fluorescence polarization based IMAP assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-Ethoxy-6-chloro-5-azaindazoles as Novel PDE4 Inhibitors for the Treatment of Alcohol Use Disorder and Alcoholic Liver Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 7.26 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5563001 | — | — | 1 | 7.78 |
| CHEMBL5567204 | — | — | 1 | 7.70 |
| CHEMBL5590959 | — | — | 1 | 7.59 |
| CHEMBL5570546 | — | — | 1 | 7.43 |
| CHEMBL5575493 | — | — | 1 | 7.41 |
| CHEMBL5568942 | — | — | 1 | 7.33 |
| CHEMBL5566545 | — | — | 1 | 7.29 |
| CHEMBL5563029 | — | — | 1 | 7.15 |
| CHEMBL5574297 | — | — | 1 | 7.03 |
| CHEMBL5592515 | — | — | 1 | 6.64 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.49 |
| CHEMBL5564470 | — | — | 1 | - |
| CHEMBL5595928 | — | — | 1 | - |
| CHEMBL5571738 | — | — | 1 | - |
| CHEMBL5570756 | — | — | 1 | - |
| CHEMBL5575915 | — | — | 1 | - |
| CHEMBL5573041 | — | — | 1 | - |
| CHEMBL5569037 | — | — | 1 | - |
| CHEMBL5579659 | — | — | 1 | - |
| CHEMBL5594433 | — | — | 1 | - |
| CHEMBL5595427 | — | — | 1 | - |
| CHEMBL5595032 | — | — | 1 | - |
| CHEMBL5569925 | — | — | 1 | - |
| CHEMBL5570980 | — | — | 1 | - |
| CHEMBL5570240 | — | — | 1 | - |
| CHEMBL5590059 | — | — | 1 | - |
| CHEMBL5584181 | — | — | 1 | - |
| CHEMBL5591926 | — | — | 1 | - |
| CHEMBL5570894 | — | — | 1 | - |
| CHEMBL5573189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5563001 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL5567204 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL5590959 | — | IC50 | = | 25.6 | nM | 7.59 |
| CHEMBL5570546 | — | IC50 | = | 37.4 | nM | 7.43 |
| CHEMBL5575493 | — | IC50 | = | 38.7 | nM | 7.41 |
| CHEMBL5568942 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL5566545 | — | IC50 | = | 51.7 | nM | 7.29 |
| CHEMBL5563029 | — | IC50 | = | 71.3 | nM | 7.15 |
| CHEMBL5574297 | — | IC50 | = | 92.7 | nM | 7.03 |
| CHEMBL5592515 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL5595928 | — | IC50 | - | — | - | |
| CHEMBL5574788 | — | IC50 | - | — | - | |
| CHEMBL5564470 | — | IC50 | - | — | - | |
| CHEMBL5569279 | — | IC50 | - | — | - | |
| CHEMBL5571426 | — | IC50 | - | — | - | |
| CHEMBL5571695 | — | IC50 | - | — | - | |
| CHEMBL5574916 | — | IC50 | - | — | - | |
| CHEMBL5565223 | — | IC50 | - | — | - | |
| CHEMBL5570767 | — | IC50 | - | — | - | |
| CHEMBL5573894 | — | IC50 | - | — | - | |
| CHEMBL5575635 | — | IC50 | - | — | - | |
| CHEMBL5564007 | — | IC50 | - | — | - | |
| CHEMBL5568801 | — | IC50 | - | — | - | |
| CHEMBL5568706 | — | IC50 | - | — | - | |
| CHEMBL5589872 | — | IC50 | - | — | - | |
| CHEMBL5570403 | — | IC50 | - | — | - | |
| CHEMBL5574435 | — | IC50 | - | — | - | |
| CHEMBL5595032 | — | IC50 | - | — | - | |
| CHEMBL5573189 | — | IC50 | - | — | - | |
| CHEMBL5570894 | — | IC50 | - | — | - | |
| CHEMBL5591926 | — | IC50 | - | — | - | |
| CHEMBL5584181 | — | IC50 | - | — | - | |
| CHEMBL5590059 | — | IC50 | - | — | - | |
| CHEMBL5570240 | — | IC50 | - | — | - | |
| CHEMBL5570980 | — | IC50 | - | — | - | |
| CHEMBL5569925 | — | IC50 | - | — | - | |
| CHEMBL5571738 | — | IC50 | - | — | - | |
| CHEMBL5595427 | — | IC50 | - | — | - | |
| CHEMBL5594433 | — | IC50 | - | — | - | |
| CHEMBL5579659 | — | IC50 | - | — | - | |
| CHEMBL5569037 | — | IC50 | - | — | - | |
| CHEMBL5573041 | — | IC50 | - | — | - | |
| CHEMBL5575915 | — | IC50 | - | — | - | |
| CHEMBL5570756 | — | IC50 | - | — | - |