Assay Detail
Functional
CHEMBL5535136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protection against TSZ-induced necroptosis in human HT-29 cells preincubated with compound followed by TNA-alpha,Smac mimetic and Z-VAD-FMK addition and measured after 24 hrs by CCK-8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 10.02 | 10.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5594666 | — | — | 1 | 10.62 |
| CHEMBL5574073 | — | — | 1 | 10.59 |
| CHEMBL5570441 | — | — | 1 | 10.57 |
| CHEMBL5595640 | — | — | 1 | 10.49 |
| CHEMBL5572223 | — | — | 1 | 10.23 |
| CHEMBL5572422 | — | — | 1 | 10.05 |
| CHEMBL5570334 | — | — | 1 | 10.03 |
| CHEMBL5593492 | — | — | 1 | 10.00 |
| CHEMBL5592340 | — | — | 1 | 10.00 |
| CHEMBL5570304 | — | — | 1 | 9.98 |
| CHEMBL5591986 | — | — | 1 | 9.97 |
| CHEMBL5575605 | — | — | 1 | 9.95 |
| CHEMBL5570431 | — | — | 1 | 9.91 |
| CHEMBL5571760 | — | — | 1 | 9.89 |
| CHEMBL5403081 | — | — | 1 | 8.00 |
| CHEMBL5564492 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5594666 | — | EC50 | = | 0.024 | nM | 10.62 |
| CHEMBL5574073 | — | EC50 | = | 0.026 | nM | 10.59 |
| CHEMBL5570441 | — | EC50 | = | 0.027 | nM | 10.57 |
| CHEMBL5595640 | — | EC50 | = | 0.032 | nM | 10.49 |
| CHEMBL5572223 | — | EC50 | = | 0.059 | nM | 10.23 |
| CHEMBL5572422 | — | EC50 | = | 0.09 | nM | 10.05 |
| CHEMBL5570334 | — | EC50 | = | 0.094 | nM | 10.03 |
| CHEMBL5593492 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5592340 | — | EC50 | = | 0.101 | nM | 10.00 |
| CHEMBL5570304 | — | EC50 | = | 0.105 | nM | 9.98 |
| CHEMBL5591986 | — | EC50 | = | 0.107 | nM | 9.97 |
| CHEMBL5575605 | — | EC50 | = | 0.113 | nM | 9.95 |
| CHEMBL5570431 | — | EC50 | = | 0.123 | nM | 9.91 |
| CHEMBL5571760 | — | EC50 | = | 0.128 | nM | 9.89 |
| CHEMBL5403081 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5564492 | — | EC50 | = | 0.003 | nM | - |