Assay Detail
Binding
CHEMBL5535231
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Displacement of [3H]AVP from human Vasopressin V2 receptor assessed as inhibition constant by Cheng-Prusoff equation analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.80 | 5.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5574495 | — | — | 1 | 5.93 |
| CHEMBL4297183 | BALOVAPTAN | 3.0 | 1 | 5.80 |
| CHEMBL5579703 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5574495 | — | Ki | = | 1170.0 | nM | 5.93 |
| CHEMBL4297183 | BALOVAPTAN | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL5579703 | — | Ki | = | 2190.0 | nM | 5.66 |