Assay Detail
Toxicity
CHEMBL5535232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG expressed in CHO cells at -80 mV holding potential incubated for 7 to 10 mins by automated patch clamp method
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.02 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5563627 | — | — | 1 | 5.46 |
| CHEMBL5571665 | — | — | 1 | 5.46 |
| CHEMBL5579703 | — | — | 1 | 5.43 |
| CHEMBL5567358 | — | — | 1 | 5.42 |
| CHEMBL5574495 | — | — | 1 | 5.40 |
| CHEMBL5571796 | — | — | 1 | 4.99 |
| CHEMBL5573173 | — | — | 1 | 4.92 |
| CHEMBL5565555 | — | — | 1 | 4.89 |
| CHEMBL5575102 | — | — | 1 | 4.86 |
| CHEMBL5563327 | — | — | 1 | 4.78 |
| CHEMBL5572381 | — | — | 1 | 4.72 |
| CHEMBL4297183 | BALOVAPTAN | 3.0 | 1 | 4.68 |
| CHEMBL5573091 | — | — | 1 | 4.67 |
| CHEMBL5572870 | — | — | 1 | 4.64 |
| CHEMBL5594885 | — | — | 1 | - |
| CHEMBL5571184 | — | — | 1 | - |
| CHEMBL5542954 | — | — | 1 | - |
| CHEMBL5571560 | — | — | 1 | - |
| CHEMBL5563054 | — | — | 1 | - |
| CHEMBL5573279 | — | — | 1 | - |
| CHEMBL5570369 | — | — | 1 | - |
| CHEMBL5574628 | — | — | 1 | - |
| CHEMBL5574305 | — | — | 1 | - |
| CHEMBL5570415 | — | — | 1 | - |
| CHEMBL5070261 | — | — | 1 | - |
| CHEMBL5070075 | — | — | 1 | - |
| CHEMBL5074709 | — | — | 1 | - |
| CHEMBL5570184 | — | — | 1 | - |
| CHEMBL5574481 | — | — | 1 | - |
| CHEMBL5549819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5563627 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5571665 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5579703 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5567358 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5574495 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5571796 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5573173 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5565555 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5575102 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL5563327 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL5572381 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4297183 | BALOVAPTAN | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5573091 | — | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL5572870 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5568795 | — | IC50 | - | — | - | |
| CHEMBL5566522 | — | IC50 | - | — | - | |
| CHEMBL5569782 | — | IC50 | - | — | - | |
| CHEMBL5572998 | — | IC50 | - | — | - | |
| CHEMBL5575000 | — | IC50 | - | — | - | |
| CHEMBL5565605 | — | IC50 | - | — | - | |
| CHEMBL5564603 | — | IC50 | - | — | - | |
| CHEMBL5575561 | — | IC50 | - | — | - | |
| CHEMBL5573085 | — | IC50 | - | — | - | |
| CHEMBL5594885 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5571184 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5542954 | — | IC50 | - | — | - | |
| CHEMBL5571560 | — | IC50 | - | — | - | |
| CHEMBL5563054 | — | IC50 | - | — | - | |
| CHEMBL5573279 | — | IC50 | - | — | - | |
| CHEMBL5570369 | — | IC50 | - | — | - | |
| CHEMBL5574628 | — | IC50 | - | — | - | |
| CHEMBL5574305 | — | IC50 | - | — | - | |
| CHEMBL5570415 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5070261 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5070075 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5074709 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5570184 | — | IC50 | - | — | - | |
| CHEMBL5574481 | — | IC50 | - | — | - | |
| CHEMBL5549819 | — | IC50 | - | — | - |