Assay Detail
Functional
CHEMBL5535429
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Antiproliferative activity against human HepG2 cells incubated by 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances of tryptanthrin and its derivatives as potential anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.26 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1098875 | — | — | 1 | 5.71 |
| CHEMBL307480 | — | — | 1 | 5.53 |
| CHEMBL3086870 | — | — | 1 | 5.25 |
| CHEMBL5575282 | — | — | 1 | 5.23 |
| CHEMBL5571151 | — | — | 1 | 5.20 |
| CHEMBL432537 | — | — | 1 | 5.10 |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | 5.02 |
| CHEMBL5572319 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1098875 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL307480 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL3086870 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL5575282 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL5571151 | — | IC50 | = | 6260.0 | nM | 5.20 |
| CHEMBL432537 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL306946 | TRYPTANTHRIN | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL5572319 | — | IC50 | = | 9840.0 | nM | 5.01 |