Assay Detail
Binding
CHEMBL5535547
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Inhibition of bovine liver arginase 1 using L-arginine as substrate incubated for 60 mins by OPA-p colorimetric assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A colorimetric assay adapted to fragment screening revealing aurones and chalcones as new arginase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 3.69 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4244287 | — | — | 1 | 4.64 |
| CHEMBL69863 | PICEATANNOL | — | 1 | 4.14 |
| CHEMBL225618 | — | — | 1 | 4.04 |
| CHEMBL127409 | 3,4,2',4',6'-PENTAHYDROXYCHALCONE | — | 1 | 4.01 |
| CHEMBL126669 | — | — | 1 | 3.99 |
| CHEMBL1966973 | — | — | 1 | 3.87 |
| CHEMBL3298066 | — | — | 1 | 3.60 |
| CHEMBL4092149 | — | — | 1 | 3.52 |
| CHEMBL129510 | — | — | 1 | 3.46 |
| CHEMBL341135 | — | — | 1 | 3.45 |
| CHEMBL307145 | PYROGALLOL | -1.0 | 1 | 3.43 |
| CHEMBL490355 | SULFURETIN | — | 1 | 3.36 |
| CHEMBL83598 | — | — | 1 | 3.27 |
| CHEMBL128000 | BUTEIN | — | 1 | 2.81 |
| CHEMBL5569120 | — | — | 1 | - |
| CHEMBL284616 | CHLOROGENIC ACID | 2.0 | 1 | - |
| CHEMBL5542169 | — | — | 1 | - |
| CHEMBL5566804 | — | — | 1 | - |
| CHEMBL5566427 | — | — | 1 | - |
| CHEMBL5570847 | — | — | 1 | - |
| CHEMBL5568623 | — | — | 1 | - |
| CHEMBL5571615 | — | — | 1 | - |
| CHEMBL5566704 | — | — | 1 | - |
| CHEMBL5563348 | — | — | 1 | - |
| CHEMBL5566740 | — | — | 1 | - |
| CHEMBL5571900 | — | — | 1 | - |
| CHEMBL5574312 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4244287 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL69863 | PICEATANNOL | IC50 | = | 71600.0 | nM | 4.14 |
| CHEMBL225618 | — | IC50 | = | 91100.0 | nM | 4.04 |
| CHEMBL127409 | 3,4,2',4',6'-PENTAHYDROXYCHALCONE | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL126669 | — | IC50 | = | 102000.0 | nM | 3.99 |
| CHEMBL1966973 | — | IC50 | = | 136000.0 | nM | 3.87 |
| CHEMBL3298066 | — | IC50 | = | 254000.0 | nM | 3.60 |
| CHEMBL4092149 | — | IC50 | = | 302000.0 | nM | 3.52 |
| CHEMBL129510 | — | IC50 | = | 351000.0 | nM | 3.46 |
| CHEMBL341135 | — | IC50 | = | 354000.0 | nM | 3.45 |
| CHEMBL307145 | PYROGALLOL | IC50 | = | 375000.0 | nM | 3.43 |
| CHEMBL490355 | SULFURETIN | IC50 | = | 437000.0 | nM | 3.36 |
| CHEMBL83598 | — | IC50 | = | 537000.0 | nM | 3.27 |
| CHEMBL128000 | BUTEIN | IC50 | = | 1551000.0 | nM | 2.81 |
| CHEMBL5569120 | — | IC50 | = | 364000.0 | nM | - |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | = | 271000.0 | nM | - |
| CHEMBL5542169 | — | IC50 | = | 720000.0 | nM | - |
| CHEMBL5566804 | — | IC50 | = | 764000.0 | nM | - |
| CHEMBL5566427 | — | IC50 | = | 507000.0 | nM | - |
| CHEMBL5570847 | — | IC50 | = | 135000.0 | nM | - |
| CHEMBL5568623 | — | IC50 | = | 384000.0 | nM | - |
| CHEMBL5571615 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL5566704 | — | IC50 | = | 1925000.0 | nM | - |
| CHEMBL5563348 | — | IC50 | = | 532000.0 | nM | - |
| CHEMBL5566740 | — | IC50 | = | 287000.0 | nM | - |
| CHEMBL5571900 | — | IC50 | = | 1091000.0 | nM | - |
| CHEMBL5574312 | — | IC50 | = | 312000.0 | nM | - |