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Assay Detail

CHEMBL5535692

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Functional
Antiviral activity against Human rhinovirus 16 infected in human HeLa cells assessed as inhibition of viral replication measured after 48 hrs
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism rhinovirus A16
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

rhinovirus A16 (CHEMBL613769)
Type ORGANISM
Organism rhinovirus A16

Publication

4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections.
Barbieri F, Carlen V, Martina MG, Sannio F, Cancade S, Perini C, Restori M, Crespan E, Maga G, Docquier JD, Cagno V, Radi M.
RSC Med Chem (2024) 15 : 1589 -1600
PubMed 38784463 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.54 6.60
EC50 2 8.01 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20210 RUPINTRIVIR 2.0 1 8.70
CHEMBL283403 ENVIROXIME 2.0 1 7.31
CHEMBL5570656 1 6.60
CHEMBL5568991 1 6.31
CHEMBL5571041 1 5.74
CHEMBL5565351 1 5.61
CHEMBL5565303 1 5.04
CHEMBL5567055 1 5.02
CHEMBL5569384 1 5.01
CHEMBL5571202 1 4.98
CHEMBL5574169 1 -
CHEMBL5571849 1 -
CHEMBL5563832 1 -
CHEMBL5567548 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20210 RUPINTRIVIR EC50 = 2.0 nM 8.70
CHEMBL283403 ENVIROXIME EC50 = 49.0 nM 7.31
CHEMBL5570656 IC50 = 250.0 nM 6.60
CHEMBL5568991 IC50 = 490.0 nM 6.31
CHEMBL5571041 IC50 = 1820.0 nM 5.74
CHEMBL5565351 IC50 = 2440.0 nM 5.61
CHEMBL5565303 IC50 = 9020.0 nM 5.04
CHEMBL5567055 IC50 = 9520.0 nM 5.02
CHEMBL5569384 IC50 = 9770.0 nM 5.01
CHEMBL5571202 IC50 = 10370.0 nM 4.98
CHEMBL5574169 IC50 - -
CHEMBL5571849 IC50 - -
CHEMBL5563832 IC50 - -
CHEMBL5567548 IC50 - -