Assay Detail
Functional
CHEMBL5535759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human Eca-109/VCR cells assessed as lapatinib IC50 incubated for 48 hrs by CCK-8 assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Eca-109/VCR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new tricyclic spiroindole derivatives as potent P-glycoprotein inhibitors for reversing multidrug resistance enabled by a synthetic methodology-based library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.31 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5566285 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5566285 | — | IC50 | = | 4910.0 | nM | 5.31 |