Assay Detail
Functional
CHEMBL5535841
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human T24 cells incubated for 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-24 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, docking optimization, and evaluation of biotin-PEG4-1,8-naphthalimide as a potent and safe antitumor agent with dual targeting of ferroptosis and DNA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.08 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | 2.0 | 1 | 7.92 |
| CHEMBL5076056 | — | — | 1 | 5.23 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.10 |
| CHEMBL5565843 | — | — | 1 | - |
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43482 | MITONAFIDE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5076056 | — | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL5565843 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL810 | TEMOZOLOMIDE | IC50 | - | — | - |