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Assay Detail

CHEMBL5536201

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human CAL-27 cells incubated for 48 hrs by XTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CAL-27
Confidence 1 — Organism
Curated By Autocuration

Target

CAL-27 (CHEMBL1075408)
Type CELL-LINE
Organism Homo sapiens

Publication

A Potent Solution for Tumor Growth and Angiogenesis Suppression via an ELR<sup>+</sup>CXCL-CXCR1/2 Pathway Inhibitor.
Grytsai O, Dufies M, Le Du J, Rastoin O, Pires Gonçalves LC, Mateo L, Lacas-Gervais S, Cao Y, Demange L, Pagès G, Benhida R, Ronco C.
ACS Med Chem Lett (2024) 15 : 845 -856
PubMed 38894897 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 5.19 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5579669 1 6.00
CHEMBL5568805 1 5.60
CHEMBL5549970 1 5.52
CHEMBL5572121 1 5.40
CHEMBL4799715 1 5.30
CHEMBL5570017 1 5.30
CHEMBL5572632 1 5.16
CHEMBL5570076 1 5.16
CHEMBL5572383 1 5.16
CHEMBL5565327 1 5.10
CHEMBL5583611 1 4.60
CHEMBL4550904 1 4.60
CHEMBL5568724 1 4.60
CHEMBL5593327 1 -
CHEMBL5575595 1 -
CHEMBL5564096 1 -
CHEMBL5594187 1 -
CHEMBL5572155 1 -
CHEMBL5570451 1 -
CHEMBL5570892 1 -
CHEMBL5567361 1 -
CHEMBL5573651 1 -
CHEMBL5594473 1 -
CHEMBL5575771 1 -
CHEMBL5555259 1 -
CHEMBL5563240 1 -
CHEMBL5568819 1 -
CHEMBL5573468 1 -
CHEMBL5590695 1 -
CHEMBL5571576 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5579669 IC50 = 1000.0 nM 6.00
CHEMBL5568805 IC50 = 2500.0 nM 5.60
CHEMBL5549970 IC50 = 3000.0 nM 5.52
CHEMBL5572121 IC50 = 4000.0 nM 5.40
CHEMBL4799715 IC50 = 5000.0 nM 5.30
CHEMBL5570017 IC50 = 5000.0 nM 5.30
CHEMBL5572632 IC50 = 7000.0 nM 5.16
CHEMBL5570076 IC50 = 7000.0 nM 5.16
CHEMBL5572383 IC50 = 7000.0 nM 5.16
CHEMBL5565327 IC50 = 8000.0 nM 5.10
CHEMBL5568724 IC50 = 25000.0 nM 4.60
CHEMBL4550904 IC50 = 25000.0 nM 4.60
CHEMBL5583611 IC50 = 25000.0 nM 4.60
CHEMBL5573045 IC50 > 25000.0 nM -
CHEMBL5591275 IC50 > 25000.0 nM -
CHEMBL5593327 IC50 > 25000.0 nM -
CHEMBL5575595 IC50 > 25000.0 nM -
CHEMBL5564096 IC50 > 25000.0 nM -
CHEMBL5594187 IC50 > 25000.0 nM -
CHEMBL5572155 IC50 > 25000.0 nM -
CHEMBL5570451 IC50 > 25000.0 nM -
CHEMBL5570892 IC50 > 25000.0 nM -
CHEMBL5567361 IC50 > 25000.0 nM -
CHEMBL5573651 IC50 > 10000.0 nM -
CHEMBL5594473 IC50 > 25000.0 nM -
CHEMBL5575771 IC50 > 25000.0 nM -
CHEMBL5555259 IC50 > 10000.0 nM -
CHEMBL5563240 IC50 > 25000.0 nM -
CHEMBL5568819 IC50 > 25000.0 nM -
CHEMBL5573468 IC50 > 25000.0 nM -
CHEMBL5590695 IC50 > 25000.0 nM -
CHEMBL5571576 IC50 > 25000.0 nM -