Assay Detail
Binding
CHEMBL5536340
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ERK5 in human SN12C cells assessed as luciferase activity by Bright-Glo luminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SN12C |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Imidazopyridine Compounds as ERK5 Inhibitors for Treating Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.11 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555328 | — | — | 1 | 8.30 |
| CHEMBL5573086 | — | — | 1 | 8.22 |
| CHEMBL5574029 | — | — | 1 | 8.05 |
| CHEMBL5569331 | — | — | 1 | 8.05 |
| CHEMBL5571189 | — | — | 1 | 8.05 |
| CHEMBL5566766 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555328 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5573086 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5574029 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5569331 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5571189 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5566766 | — | IC50 | = | 10.0 | nM | 8.00 |