Assay Detail
Binding
CHEMBL5536362
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Inhibition of human Cathepsin B using Z-Phe-Arg-AMC as substrate by fluorescence based assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural Modifications of Covalent Cathepsin S Inhibitors: Impact on Affinity, Selectivity, and Permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.37 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591918 | — | — | 1 | 7.44 |
| CHEMBL5573840 | — | — | 1 | 7.19 |
| CHEMBL5574900 | — | — | 1 | 7.09 |
| CHEMBL5575199 | — | — | 1 | 6.85 |
| CHEMBL5566228 | — | — | 1 | 6.80 |
| CHEMBL347111 | — | — | 1 | 5.98 |
| CHEMBL249915 | — | — | 1 | 5.78 |
| CHEMBL5572314 | — | — | 1 | 5.78 |
| CHEMBL356155 | — | — | 1 | 5.72 |
| CHEMBL153239 | — | — | 1 | 5.11 |
| CHEMBL5573367 | — | — | 1 | - |
| CHEMBL5592727 | — | — | 1 | - |
| CHEMBL5571616 | — | — | 1 | - |
| CHEMBL5574337 | — | — | 1 | - |
| CHEMBL2207560 | — | — | 1 | - |
| CHEMBL5564109 | — | — | 1 | - |
| CHEMBL5567080 | — | — | 1 | - |
| CHEMBL5595801 | — | — | 1 | - |
| CHEMBL5549958 | — | — | 1 | - |
| CHEMBL5593543 | — | — | 1 | - |
| CHEMBL5570914 | — | — | 1 | - |
| CHEMBL5590540 | — | — | 1 | - |
| CHEMBL5572340 | — | — | 1 | - |
| CHEMBL5594049 | — | — | 1 | - |
| CHEMBL5589673 | — | — | 1 | - |
| CHEMBL5567047 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591918 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL5573840 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL5574900 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL5575199 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL5566228 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL347111 | — | Ki | = | 1054.0 | nM | 5.98 |
| CHEMBL249915 | — | Ki | = | 1670.0 | nM | 5.78 |
| CHEMBL5572314 | — | Ki | = | 1667.0 | nM | 5.78 |
| CHEMBL356155 | — | Ki | = | 1906.0 | nM | 5.72 |
| CHEMBL153239 | — | Ki | = | 7847.0 | nM | 5.11 |
| CHEMBL5573367 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL5592727 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL5571616 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL5574337 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL2207560 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL5564109 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL5567080 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL5595801 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL5549958 | — | Ki | > | 12000.0 | nM | - |
| CHEMBL5593543 | — | Ki | - | — | - | |
| CHEMBL5570914 | — | Ki | > | 510.0 | nM | - |
| CHEMBL5590540 | — | Ki | > | 12.0 | nM | - |
| CHEMBL5572340 | — | Ki | > | 2550.0 | nM | - |
| CHEMBL5594049 | — | Ki | > | 10.0 | nM | - |
| CHEMBL5589673 | — | Ki | > | 2550.0 | nM | - |
| CHEMBL5567047 | — | Ki | - | — | - |