Assay Detail
Binding
CHEMBL5536376
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Binding affinity to recombinant His-tagged human TIM-3 expressed in HEK293 assessed as dissociation constant by SPR analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Hepatitis A virus cellular receptor 2 (CHEMBL4630879) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Rational Design of Constrained Peptides as TIM-3 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 5.94 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571782 | — | — | 1 | 6.80 |
| CHEMBL5575871 | — | — | 1 | 6.57 |
| CHEMBL5575027 | — | — | 1 | 6.48 |
| CHEMBL5567449 | — | — | 1 | 6.41 |
| CHEMBL5573426 | — | — | 1 | 6.12 |
| CHEMBL5542747 | — | — | 1 | 5.72 |
| CHEMBL5562869 | — | — | 1 | 5.57 |
| CHEMBL5549921 | — | — | 1 | 5.39 |
| CHEMBL5574715 | — | — | 1 | 5.32 |
| CHEMBL5575353 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571782 | — | Kd | = | 160.0 | nM | 6.80 |
| CHEMBL5575871 | — | Kd | = | 270.0 | nM | 6.57 |
| CHEMBL5575027 | — | Kd | = | 330.0 | nM | 6.48 |
| CHEMBL5567449 | — | Kd | = | 390.0 | nM | 6.41 |
| CHEMBL5573426 | — | Kd | = | 750.0 | nM | 6.12 |
| CHEMBL5542747 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL5562869 | — | Kd | = | 2700.0 | nM | 5.57 |
| CHEMBL5549921 | — | Kd | = | 4100.0 | nM | 5.39 |
| CHEMBL5574715 | — | Kd | = | 4800.0 | nM | 5.32 |
| CHEMBL5575353 | — | Kd | = | 9700.0 | nM | 5.01 |