Assay Detail
Toxicity
CHEMBL5536459
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Inhibition of human recombinant MAO-B using benzylamine as substrate
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and Synthesis of the Linezolid Bioisosteres to Resolve the Serotonergic Toxicity Associated with Linezolid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.97 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126 | LINEZOLID | 4.0 | 1 | 6.21 |
| CHEMBL5573453 | — | — | 1 | 5.53 |
| CHEMBL5592619 | — | — | 1 | 4.95 |
| CHEMBL5590251 | — | — | 1 | 4.88 |
| CHEMBL5575301 | — | — | 1 | 4.59 |
| CHEMBL2337836 | — | — | 1 | 4.56 |
| CHEMBL5075183 | — | — | 1 | 4.52 |
| CHEMBL5082239 | — | — | 1 | 4.48 |
| CHEMBL5569307 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126 | LINEZOLID | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL5573453 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL5592619 | — | IC50 | = | 11360.0 | nM | 4.95 |
| CHEMBL5590251 | — | IC50 | = | 13150.0 | nM | 4.88 |
| CHEMBL5575301 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL2337836 | — | IC50 | = | 27310.0 | nM | 4.56 |
| CHEMBL5075183 | — | IC50 | = | 30290.0 | nM | 4.52 |
| CHEMBL5082239 | — | IC50 | = | 33120.0 | nM | 4.48 |
| CHEMBL5569307 | — | IC50 | > | 40000.0 | nM | - |