Assay Detail
Binding
CHEMBL5536652
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Inhibition of recombinant human PARP1 using HRP as substrate by ELISA analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule targeted therapies for endometrial cancer: progress, challenges, and opportunities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.43 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 1 | 9.24 |
| CHEMBL3765528 | — | — | 1 | 8.74 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | 8.71 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 8.70 |
| CHEMBL506871 | VELIPARIB | 3.0 | 1 | 8.32 |
| CHEMBL3764816 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL3765528 | — | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 1.94 | nM | 8.71 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 1.98 | nM | 8.70 |
| CHEMBL506871 | VELIPARIB | IC50 | = | 4.73 | nM | 8.32 |
| CHEMBL3764816 | — | IC50 | = | 144.0 | nM | 6.84 |