Assay Detail
Binding
CHEMBL5537009
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Inhibition of bovine IAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 mins by luminescence based analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Unveiling sultam in drug discovery: spotlight on the underexplored scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.01 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5573727 | — | — | 1 | 6.42 |
| CHEMBL5591327 | — | — | 1 | 6.29 |
| CHEMBL5562695 | — | — | 1 | 6.17 |
| CHEMBL5562714 | — | — | 1 | 5.95 |
| CHEMBL5591314 | — | — | 1 | 5.77 |
| CHEMBL5562682 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5573727 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5591327 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5562695 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5562714 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5591314 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5562682 | — | IC50 | = | 3480.0 | nM | 5.46 |