Assay Detail
Functional
CHEMBL5537355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in african green monkey Vero E6 cells assessed as inhibition of virus-induced cytopathic effect measured after 72 hrs by crystal violet staining based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.21 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852855 | — | — | 1 | 7.52 |
| CHEMBL92708 | CALPEPTIN | — | 1 | 7.14 |
| CHEMBL5593485 | — | — | 1 | 6.82 |
| CHEMBL5564834 | — | — | 1 | 6.43 |
| CHEMBL5266148 | — | — | 1 | 6.31 |
| CHEMBL5560356 | — | — | 1 | 6.28 |
| CHEMBL5195325 | — | — | 1 | 6.07 |
| CHEMBL3427166 | — | — | 1 | 6.04 |
| CHEMBL4850298 | — | — | 1 | 5.82 |
| CHEMBL1255891 | NARLAPREVIR | 3.0 | 1 | 5.11 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 4.81 |
| CHEMBL5171771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852855 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL92708 | CALPEPTIN | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL5593485 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5564834 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5266148 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5560356 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5195325 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3427166 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4850298 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1255891 | NARLAPREVIR | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 15570.0 | nM | 4.81 |
| CHEMBL5171771 | — | EC50 | > | 10.0 | nM | - |