Assay Detail
Binding
CHEMBL5537359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to SARS-CoV MPro transfected in Escherichia coli BL21 (DE3) assessed as inhibition constant by FRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1a (CHEMBL3927) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.04 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852855 | — | — | 1 | 7.28 |
| CHEMBL1718454 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852855 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL1718454 | — | Ki | = | 16100.0 | nM | 4.79 |