Assay Detail
Functional
CHEMBL5537361
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV infected in african green monkey Vero E6 cells assessed as inhibition of virus-induced cytopathic effect measured after 72 hrs by crystal violet staining based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV (CHEMBL4303836) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.59 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852855 | — | — | 1 | 6.22 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 6.11 |
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 5.90 |
| CHEMBL501849 | SIMEPREVIR | 4.0 | 1 | 5.85 |
| CHEMBL5395482 | — | — | 1 | 5.35 |
| CHEMBL337173 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852855 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL584 | NELFINAVIR | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL607707 | PELITINIB | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL501849 | SIMEPREVIR | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5395482 | — | EC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL337173 | — | EC50 | = | 77000.0 | nM | 4.11 |