Assay Detail
Functional
CHEMBL5537367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral growth
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.42 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5266148 | — | — | 1 | 6.31 |
| CHEMBL5573557 | — | — | 1 | 5.60 |
| CHEMBL1096283 | — | — | 1 | 5.45 |
| CHEMBL5568631 | — | — | 1 | 5.30 |
| CHEMBL5593969 | — | — | 1 | 5.07 |
| CHEMBL218394 | BOCEPREVIR | 4.0 | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5266148 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5573557 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1096283 | — | EC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL5568631 | — | EC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL5593969 | — | EC50 | = | 8520.0 | nM | 5.07 |
| CHEMBL218394 | BOCEPREVIR | EC50 | = | 15570.0 | nM | 4.81 |