Assay Detail
Functional
CHEMBL5537378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral replication measured after 5 days microscopic analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.20 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 5.70 |
| CHEMBL2095208 | COBICISTAT | 4.0 | 1 | 5.56 |
| CHEMBL93553 | — | — | 1 | 4.92 |
| CHEMBL460499 | CARMOFUR | 2.0 | 1 | 4.61 |
| CHEMBL2311740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1163 | ATAZANAVIR | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2095208 | COBICISTAT | EC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL93553 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL460499 | CARMOFUR | EC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL2311740 | — | EC50 | > | 20000.0 | nM | - |