Assay Detail
Functional
CHEMBL5537640
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Protection against cisplatin-induced cytotoxicity in HEK293T cells assessed as cell viability measured after 24 to 48 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 3-hydroxypyridin-4(1H)-One derivatives as ferroptosis inhibitors with iron-chelating and reactive oxygen species scavenging activities and therapeutic effect in cisplatin-induced cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.75 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3633556 | — | — | 1 | 5.25 |
| CHEMBL5572801 | — | — | 1 | 4.60 |
| CHEMBL70927 | DEFERIPRONE | 4.0 | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3633556 | — | EC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL5572801 | — | EC50 | = | 24890.0 | nM | 4.60 |
| CHEMBL70927 | DEFERIPRONE | EC50 | = | 40000.0 | nM | 4.40 |