Assay Detail
Binding
CHEMBL5537731
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Inhibition of HDAC11 (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
5-(Trifluoromethyl)-1,2,4-oxadiazole (TFMO)-based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.18 | 4.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3692688 | — | — | 1 | 4.18 |
| CHEMBL5563683 | — | — | 1 | - |
| CHEMBL5572470 | — | — | 1 | - |
| CHEMBL5571546 | — | — | 1 | - |
| CHEMBL5575926 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3692688 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL5563683 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5572470 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5571546 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5575926 | — | IC50 | > | 100000.0 | nM | - |