Assay Detail
Functional
CHEMBL5537765
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Antiproliferative activity against human CAL-27 cells overexpressing HDAC4 assessed as inhibition of cell growth incubated for 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
5-(Trifluoromethyl)-1,2,4-oxadiazole (TFMO)-based highly selective class IIa HDAC inhibitors exhibit synergistic anticancer activity in combination with bortezomib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.86 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 5.33 |
| CHEMBL3692688 | — | — | 1 | 5.06 |
| CHEMBL4456445 | — | — | 1 | 4.89 |
| CHEMBL5571546 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL3692688 | — | IC50 | = | 8630.0 | nM | 5.06 |
| CHEMBL4456445 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL5571546 | — | IC50 | = | 69800.0 | nM | 4.16 |