Assay Detail
Binding
CHEMBL5537995
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Inhibition of human recombinant MAO-B using tyramine as substrate incubated for 20 mins by fluorometric assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.47 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595997 | — | — | 1 | 8.72 |
| CHEMBL5568907 | — | — | 1 | 8.70 |
| CHEMBL5572636 | — | — | 1 | 8.64 |
| CHEMBL5574276 | — | — | 1 | 8.47 |
| CHEMBL5573057 | — | — | 1 | 8.47 |
| CHEMBL5595687 | — | — | 1 | 8.29 |
| CHEMBL5567290 | — | — | 1 | 7.95 |
| CHEMBL5572200 | — | — | 1 | 7.73 |
| CHEMBL5542744 | — | — | 1 | 7.65 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 7.63 |
| CHEMBL5571892 | — | — | 1 | 7.57 |
| CHEMBL5571965 | — | — | 1 | 7.50 |
| CHEMBL1201142 | RASAGILINE MESYLATE | 4.0 | 1 | 7.49 |
| CHEMBL5570452 | — | — | 1 | 7.46 |
| CHEMBL5590991 | — | — | 1 | 7.21 |
| CHEMBL5569718 | — | — | 1 | 7.01 |
| CHEMBL5566383 | — | — | 1 | 6.96 |
| CHEMBL5570896 | — | — | 1 | 6.86 |
| CHEMBL5575276 | — | — | 1 | 6.83 |
| CHEMBL5565806 | — | — | 1 | 6.36 |
| CHEMBL5567284 | — | — | 1 | 6.28 |
| CHEMBL5562510 | — | — | 1 | 6.05 |
| CHEMBL5583701 | — | — | 1 | 5.91 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595997 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5568907 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5572636 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL5574276 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5573057 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5595687 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5567290 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL5572200 | — | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL5542744 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 23.6 | nM | 7.63 |
| CHEMBL5571892 | — | IC50 | = | 26.8 | nM | 7.57 |
| CHEMBL5571965 | — | IC50 | = | 31.8 | nM | 7.50 |
| CHEMBL1201142 | RASAGILINE MESYLATE | IC50 | = | 32.3 | nM | 7.49 |
| CHEMBL5570452 | — | IC50 | = | 35.1 | nM | 7.46 |
| CHEMBL5590991 | — | IC50 | = | 62.2 | nM | 7.21 |
| CHEMBL5569718 | — | IC50 | = | 98.2 | nM | 7.01 |
| CHEMBL5566383 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL5570896 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL5575276 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL5565806 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5567284 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5562510 | — | IC50 | = | 896.0 | nM | 6.05 |
| CHEMBL5583701 | — | IC50 | = | 1233.0 | nM | 5.91 |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - |