Assay Detail
Binding
CHEMBL5537996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAO-A using tyramine as substrate incubated for 20 mins by fluorometric assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.96 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 7.47 |
| CHEMBL5568907 | — | — | 1 | 4.67 |
| CHEMBL5573057 | — | — | 1 | 4.42 |
| CHEMBL5574276 | — | — | 1 | 4.19 |
| CHEMBL5567290 | — | — | 1 | 4.07 |
| CHEMBL5570452 | — | — | 1 | - |
| CHEMBL5583701 | — | — | 1 | - |
| CHEMBL5566383 | — | — | 1 | - |
| CHEMBL5567284 | — | — | 1 | - |
| CHEMBL5572200 | — | — | 1 | - |
| CHEMBL5562510 | — | — | 1 | - |
| CHEMBL5570896 | — | — | 1 | - |
| CHEMBL5565806 | — | — | 1 | - |
| CHEMBL5542744 | — | — | 1 | - |
| CHEMBL5571892 | — | — | 1 | - |
| CHEMBL5575276 | — | — | 1 | - |
| CHEMBL1201142 | RASAGILINE MESYLATE | 4.0 | 1 | - |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
| CHEMBL5590991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5568907 | — | IC50 | = | 21220.0 | nM | 4.67 |
| CHEMBL5573057 | — | IC50 | = | 38280.0 | nM | 4.42 |
| CHEMBL5574276 | — | IC50 | = | 64440.0 | nM | 4.19 |
| CHEMBL5567290 | — | IC50 | = | 85400.0 | nM | 4.07 |
| CHEMBL5570452 | — | IC50 | = | 160640.0 | nM | - |
| CHEMBL5583701 | — | IC50 | - | — | - | |
| CHEMBL5566383 | — | IC50 | - | — | - | |
| CHEMBL5567284 | — | IC50 | - | — | - | |
| CHEMBL5572200 | — | IC50 | - | — | - | |
| CHEMBL5562510 | — | IC50 | - | — | - | |
| CHEMBL5570896 | — | IC50 | - | — | - | |
| CHEMBL5565806 | — | IC50 | - | — | - | |
| CHEMBL5542744 | — | IC50 | - | — | - | |
| CHEMBL5571892 | — | IC50 | - | — | - | |
| CHEMBL5575276 | — | IC50 | - | — | - | |
| CHEMBL1201142 | RASAGILINE MESYLATE | IC50 | - | — | - | |
| CHEMBL396778 | SAFINAMIDE | IC50 | - | — | - | |
| CHEMBL5590991 | — | IC50 | - | — | - |