Assay Detail
Functional
CHEMBL5538002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.18 | 4.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595687 | — | — | 1 | 4.36 |
| CHEMBL5573057 | — | — | 1 | 4.25 |
| CHEMBL5574276 | — | — | 1 | 4.20 |
| CHEMBL5595997 | — | — | 1 | 4.08 |
| CHEMBL5572636 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595687 | — | IC50 | = | 43310.0 | nM | 4.36 |
| CHEMBL5573057 | — | IC50 | = | 55930.0 | nM | 4.25 |
| CHEMBL5574276 | — | IC50 | = | 63090.0 | nM | 4.20 |
| CHEMBL5595997 | — | IC50 | = | 83160.0 | nM | 4.08 |
| CHEMBL5572636 | — | IC50 | = | 99290.0 | nM | 4.00 |