Assay Detail
Binding
CHEMBL5538015
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Inhibition of PDE1 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Advances in targeting Phosphodiesterase 1: From mechanisms to potential therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.59 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644729 | — | — | 1 | 8.54 |
| CHEMBL5573991 | — | — | 1 | 7.85 |
| CHEMBL4644938 | — | — | 1 | 7.10 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 6.40 |
| CHEMBL307639 | — | — | 1 | 5.10 |
| CHEMBL71752 | VINPOCETINE | 2.0 | 1 | 4.52 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644729 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5573991 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4644938 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 396.0 | nM | 6.40 |
| CHEMBL307639 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL71752 | VINPOCETINE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL113 | CAFFEINE | IC50 | = | 479000.0 | nM | - |