Assay Detail
Binding
CHEMBL5538020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE1B (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (CHEMBL4425) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Advances in targeting Phosphodiesterase 1: From mechanisms to potential therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.48 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5572993 | — | — | 1 | 9.35 |
| CHEMBL5568686 | — | — | 1 | 8.42 |
| CHEMBL5571465 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5572993 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL5568686 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL5571465 | — | IC50 | = | 21.0 | nM | 7.68 |