Assay Detail
Binding
CHEMBL5538331
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal 6His-FLAG-tagged human recombinant HDAC1 (1 to 482 residues) expressed in Sf9 cells using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by plate reader analysis
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.57 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4536105 | — | — | 1 | 8.85 |
| CHEMBL5592140 | — | — | 1 | 7.55 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.50 |
| CHEMBL5590999 | — | — | 1 | 7.47 |
| CHEMBL5574185 | — | — | 1 | 7.43 |
| CHEMBL5570737 | — | — | 1 | 7.25 |
| CHEMBL5589731 | — | — | 1 | 7.24 |
| CHEMBL4087968 | — | — | 1 | 7.13 |
| CHEMBL5571753 | — | — | 1 | 7.07 |
| CHEMBL5571617 | — | — | 1 | 7.05 |
| CHEMBL5573240 | — | — | 1 | 7.02 |
| CHEMBL5571499 | — | — | 1 | 6.91 |
| CHEMBL5570626 | — | — | 1 | 6.90 |
| CHEMBL5572480 | — | — | 1 | 6.83 |
| CHEMBL5569630 | — | — | 1 | 6.82 |
| CHEMBL5569425 | — | — | 1 | 6.76 |
| CHEMBL5572364 | — | — | 1 | 6.76 |
| CHEMBL5571672 | — | — | 1 | 6.75 |
| CHEMBL5570265 | — | — | 1 | 6.74 |
| CHEMBL5572268 | — | — | 1 | 6.71 |
| CHEMBL5570427 | — | — | 1 | 6.68 |
| CHEMBL5563440 | — | — | 1 | 6.67 |
| CHEMBL5569221 | — | — | 1 | 6.60 |
| CHEMBL5575122 | — | — | 1 | 6.60 |
| CHEMBL5572633 | — | — | 1 | 6.49 |
| CHEMBL5595751 | — | — | 1 | 6.39 |
| CHEMBL5564987 | — | — | 1 | 6.36 |
| CHEMBL5574871 | — | — | 1 | 6.28 |
| CHEMBL5569303 | — | — | 1 | 6.22 |
| CHEMBL5563957 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4536105 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5592140 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5590999 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5574185 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5570737 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5589731 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4087968 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5571753 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5571617 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5573240 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL5571499 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5570626 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL5572480 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL5569630 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL5569425 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL5572364 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5571672 | — | IC50 | = | 177.5 | nM | 6.75 |
| CHEMBL5570265 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5572268 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL5570427 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL5563440 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL5569221 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL5575122 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5572633 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL5595751 | — | IC50 | = | 405.0 | nM | 6.39 |
| CHEMBL5564987 | — | IC50 | = | 436.5 | nM | 6.36 |
| CHEMBL5574871 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL5563957 | — | IC50 | = | 595.0 | nM | 6.22 |
| CHEMBL5569303 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL5569920 | — | IC50 | = | 1308.0 | nM | 5.88 |
| CHEMBL5568791 | — | IC50 | = | 3029.0 | nM | 5.52 |
| CHEMBL5583643 | — | IC50 | = | 3062.0 | nM | 5.51 |
| CHEMBL5569757 | — | IC50 | = | 3557.0 | nM | 5.45 |
| CHEMBL5572117 | — | IC50 | = | 3924.0 | nM | 5.41 |
| CHEMBL5562535 | — | IC50 | = | 4118.0 | nM | 5.38 |
| CHEMBL5569507 | — | IC50 | = | 4708.0 | nM | 5.33 |
| CHEMBL5591487 | — | IC50 | = | 4967.0 | nM | 5.30 |
| CHEMBL5574499 | — | IC50 | = | 5260.0 | nM | 5.28 |