Assay Detail
Binding
CHEMBL5538342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human HDAC11 (1 to 347 end residues) expressed in Sf9 cells using Ac-peptide as substrate incubated for 1 hr by plate reader analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.45 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5592140 | — | — | 1 | 5.45 |
| CHEMBL5569425 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5592140 | — | IC50 | = | 3519.0 | nM | 5.45 |
| CHEMBL5569425 | — | IC50 | > | 10000.0 | nM | - |