Assay Detail
Functional
CHEMBL5538350
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse Friend leukemia cell line assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Friend leukemia cell line |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design and optimization of novel 4-methyl quinazoline derivatives as PI3K/HDAC dual inhibitors with benzamide as zinc binding moiety for the treatment of acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.46 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.96 |
| CHEMBL5592140 | — | — | 1 | 6.50 |
| CHEMBL5569425 | — | — | 1 | 6.46 |
| CHEMBL4087968 | — | — | 1 | 6.30 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5592140 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5569425 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4087968 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 810.0 | nM | 6.09 |