Assay Detail
Binding
CHEMBL5538757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6His-tagged human PIM-1 (29 to 313 residues) expressed in Escherichia coli
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting PIM kinases in cancer therapy: An update on pharmacological small-molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.66 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3105022 | — | — | 1 | 7.70 |
| CHEMBL3747545 | — | — | 1 | 7.30 |
| CHEMBL3651966 | LGH-447 | 1.0 | 1 | 6.77 |
| CHEMBL3651946 | — | — | 1 | 6.39 |
| CHEMBL3746909 | — | — | 1 | 5.96 |
| CHEMBL3651953 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3105022 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3747545 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3651966 | LGH-447 | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3651946 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL3746909 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3651953 | — | IC50 | = | 1400.0 | nM | 5.85 |