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Assay Detail

CHEMBL5538858

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against human RPE-1 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type TERT-RPE1
Confidence 1 — Organism
Curated By Autocuration

Target

TERT-RPE1 (CHEMBL615013)
Type CELL-LINE
Organism Homo sapiens

Publication

Biological evaluation of carbohydrate-based aprepitant analogs for neuroblastoma treatment.
Valdivia V, Recio R, Lerena P, Pozo E, Serrano R, Calero R, Pintado C, Leal MP, Moreno-Rodríguez N, Organero JÁ, Khiar N, Fernández I.
Eur J Med Chem (2024) 264 : 116021 -116021
PubMed 38086194 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.39 4.59

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5084694 1 4.59
CHEMBL5074991 1 4.55
CHEMBL5591943 1 4.04
CHEMBL5081321 1 -
CHEMBL5074014 1 -
CHEMBL5569983 1 -
CHEMBL5566171 1 -
CHEMBL5575729 1 -
CHEMBL5086787 1 -
CHEMBL5571815 1 -
CHEMBL5079617 1 -
CHEMBL5078626 1 -
CHEMBL1471 APREPITANT 4.0 1 -
CHEMBL5565078 1 -
CHEMBL5593237 1 -
CHEMBL5570513 1 -
CHEMBL5574494 1 -
CHEMBL5574110 1 -
CHEMBL5078603 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5084694 IC50 = 25800.0 nM 4.59
CHEMBL5074991 IC50 = 28400.0 nM 4.55
CHEMBL5591943 IC50 = 92300.0 nM 4.04
CHEMBL5081321 IC50 - -
CHEMBL5074014 IC50 - -
CHEMBL5569983 IC50 - -
CHEMBL5566171 IC50 = 251000.0 nM -
CHEMBL5575729 IC50 - -
CHEMBL5086787 IC50 = 288000.0 nM -
CHEMBL5571815 IC50 - -
CHEMBL5079617 IC50 - -
CHEMBL5078626 IC50 - -
CHEMBL1471 APREPITANT IC50 = 176300.0 nM -
CHEMBL5565078 IC50 - -
CHEMBL5593237 IC50 - -
CHEMBL5570513 IC50 - -
CHEMBL5574494 IC50 - -
CHEMBL5574110 IC50 = 145700.0 nM -
CHEMBL5078603 IC50 - -