Assay Detail
Binding
CHEMBL5539185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]WIN35428 from human DAT Y156F mutant expessed in COS-7 cells incubated for 1.5 hrs by beta scintillation counting analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.23 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3918282 | — | — | 1 | 6.94 |
| CHEMBL5592085 | — | — | 1 | 6.74 |
| CHEMBL5569659 | — | — | 1 | 6.63 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.49 |
| CHEMBL5572067 | — | — | 1 | 6.41 |
| CHEMBL3084652 | — | — | 1 | 5.90 |
| CHEMBL5571533 | — | — | 1 | 5.63 |
| CHEMBL3931765 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3918282 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL5592085 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL5569659 | — | Ki | = | 232.0 | nM | 6.63 |
| CHEMBL370805 | COCAINE | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL5572067 | — | Ki | = | 393.0 | nM | 6.41 |
| CHEMBL3084652 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL5571533 | — | Ki | = | 2360.0 | nM | 5.63 |
| CHEMBL3931765 | — | Ki | = | 7560.0 | nM | 5.12 |