Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5539301

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MV4-11 cells harboring MLL-r assessed as cell growth inhibition incubated for 5 days by CCK-8 assay
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach.
Qin S, Feng L, Zhao Q, Yan Z, Lyu X, Li K, Mu B, Chen Y, Lu W, Wang C, Suo Y, Yue J, Cui M, Li Y, Zhao Y, Duan Z, Zhu J, Lu X.
J Med Chem (2024) 67 : 1079 -1092
PubMed 38166388 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.47 6.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4588661 1 6.77
CHEMBL5579746 1 5.72
CHEMBL5572530 1 5.64
CHEMBL5595245 1 5.47
CHEMBL5579685 1 5.46
CHEMBL5573553 1 5.41
CHEMBL5574810 1 5.41
CHEMBL5573350 2 5.38
CHEMBL5592145 1 5.32
CHEMBL5591718 1 5.32
CHEMBL5562523 1 5.30
CHEMBL5574474 1 5.26
CHEMBL5572054 1 5.24
CHEMBL5565914 1 5.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4588661 IC50 = 170.0 nM 6.77
CHEMBL5579746 IC50 = 1900.0 nM 5.72
CHEMBL5572530 IC50 = 2300.0 nM 5.64
CHEMBL5595245 IC50 = 3400.0 nM 5.47
CHEMBL5579685 IC50 = 3500.0 nM 5.46
CHEMBL5573553 IC50 = 3900.0 nM 5.41
CHEMBL5574810 IC50 = 3930.0 nM 5.41
CHEMBL5573350 IC50 = 4130.0 nM 5.38
CHEMBL5592145 IC50 = 4800.0 nM 5.32
CHEMBL5591718 IC50 = 4800.0 nM 5.32
CHEMBL5562523 IC50 = 5000.0 nM 5.30
CHEMBL5574474 IC50 = 5500.0 nM 5.26
CHEMBL5572054 IC50 = 5700.0 nM 5.24
CHEMBL5573350 IC50 = 6200.0 nM 5.21
CHEMBL5565914 IC50 = 6200.0 nM 5.21