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Assay Detail

CHEMBL5539302

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Functional
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 5 days by CCK-8 assay
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Autocuration

Target

K562 (CHEMBL385)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach.
Qin S, Feng L, Zhao Q, Yan Z, Lyu X, Li K, Mu B, Chen Y, Lu W, Wang C, Suo Y, Yue J, Cui M, Li Y, Zhao Y, Duan Z, Zhu J, Lu X.
J Med Chem (2024) 67 : 1079 -1092
PubMed 38166388 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.39 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5579746 1 5.96
CHEMBL5573553 1 5.52
CHEMBL5574810 1 5.52
CHEMBL5565914 1 5.47
CHEMBL5573350 2 5.46
CHEMBL5572530 1 5.46
CHEMBL4588661 1 5.44
CHEMBL5579685 1 5.40
CHEMBL5592145 1 5.33
CHEMBL5574474 1 5.31
CHEMBL5595245 1 5.31
CHEMBL5591718 1 5.28
CHEMBL5572054 1 5.15
CHEMBL5562523 1 4.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5579746 IC50 = 1100.0 nM 5.96
CHEMBL5573553 IC50 = 3000.0 nM 5.52
CHEMBL5574810 IC50 = 3030.0 nM 5.52
CHEMBL5565914 IC50 = 3400.0 nM 5.47
CHEMBL5573350 IC50 = 3430.0 nM 5.46
CHEMBL5572530 IC50 = 3500.0 nM 5.46
CHEMBL4588661 IC50 = 3600.0 nM 5.44
CHEMBL5579685 IC50 = 4000.0 nM 5.40
CHEMBL5592145 IC50 = 4700.0 nM 5.33
CHEMBL5574474 IC50 = 4900.0 nM 5.31
CHEMBL5573350 IC50 = 4900.0 nM 5.31
CHEMBL5595245 IC50 = 4900.0 nM 5.31
CHEMBL5591718 IC50 = 5200.0 nM 5.28
CHEMBL5572054 IC50 = 7100.0 nM 5.15
CHEMBL5562523 IC50 = 12200.0 nM 4.91