Assay Detail
Functional
CHEMBL5539609
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGlu6 transfected in HEK293 cells co-transfected with chimeric Gqi9 incubated for 30 mins by IP-one HTRF assay
6
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 6 (CHEMBL3842) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, Synthesis, Pharmacology, and In Silico Studies of (1<i>S</i>,2<i>S</i>,3<i>S</i>)-2-((<i>S</i>)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu<sub>2</sub> Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.95 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5571283 | — | — | 2 | 6.61 |
| CHEMBL5570623 | — | — | 2 | 5.67 |
| CHEMBL33567 | — | — | 2 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5571283 | — | EC50 | = | 244.91 | nM | 6.61 |
| CHEMBL5571283 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5570623 | — | EC50 | = | 2137.96 | nM | 5.67 |
| CHEMBL33567 | — | EC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL33567 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5570623 | — | EC50 | = | 2500.0 | nM | 5.60 |