Assay Detail
Binding
CHEMBL5539628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Streptococcus pyogenes Sortase A N81 deletion mutant transpeptidation using IsdA64-323 as substrate preincubated for 20 mins followed by substrate addition and measured after 1.5 hrs by SDS-PAGE analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Streptococcus pyogenes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Guided Design, Synthesis, and Antivirulence Assessment of Covalent <i>Staphylococcus aureus</i> Sortase A Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.39 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5174805 | — | — | 1 | 5.47 |
| CHEMBL5570289 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5174805 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5570289 | — | IC50 | = | 4900.0 | nM | 5.31 |