Assay Detail
Functional
CHEMBL5539735
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Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiterGlo luminescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.93 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5572023 | — | — | 1 | 7.85 |
| CHEMBL4297454 | ABBV-744 | 1.0 | 1 | 7.82 |
| CHEMBL5563490 | — | — | 1 | 7.47 |
| CHEMBL5568960 | — | — | 1 | 7.35 |
| CHEMBL5568743 | — | — | 1 | 7.17 |
| CHEMBL5566025 | — | — | 1 | 6.92 |
| CHEMBL5566198 | — | — | 1 | 6.85 |
| CHEMBL5569499 | — | — | 1 | 6.62 |
| CHEMBL5568810 | — | — | 1 | 6.34 |
| CHEMBL5567469 | — | — | 1 | 6.14 |
| CHEMBL5562706 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5572023 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4297454 | ABBV-744 | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5563490 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5568960 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5568743 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5566025 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5566198 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5569499 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5568810 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5567469 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5562706 | — | IC50 | = | 2130.0 | nM | 5.67 |