Assay Detail
Binding
CHEMBL5539847
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Inhibition of Hepatitis C virus genotype 1b NS4B
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hepatitis C: The Story of a Long Journey through First, Second, and Third Generation NS3/4A Peptidomimetic Inhibitors. What Did We Learn?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.93 | 10.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5568614 | — | — | 1 | 10.89 |
| CHEMBL3786672 | — | — | 1 | 10.48 |
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 9.70 |
| CHEMBL4297647 | FURAPREVIR | 3.0 | 1 | 9.22 |
| CHEMBL5570439 | — | — | 1 | 8.57 |
| CHEMBL4525964 | VANIPREVIR | 3.0 | 1 | 8.52 |
| CHEMBL1241348 | FALDAPREVIR | 3.0 | 1 | 8.52 |
| CHEMBL3545363 | GLECAPREVIR | 4.0 | 1 | 8.05 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5568614 | — | IC50 | = | 0.013 | nM | 10.89 |
| CHEMBL3786672 | — | IC50 | = | 0.033 | nM | 10.48 |
| CHEMBL258734 | DANOPREVIR | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4297647 | FURAPREVIR | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL5570439 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4525964 | VANIPREVIR | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1241348 | FALDAPREVIR | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3545363 | GLECAPREVIR | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL231813 | TELAPREVIR | IC50 | = | 354.0 | nM | 6.45 |