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Assay Detail

CHEMBL5539848

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Hepatitis C virus infected in human Huh7.5 cells pretreated with cell for 2 hrs followed by viral infection for 1 hrs by plaque assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379)
Type ORGANISM
Organism Hepacivirus hominis

Publication

Hepatitis C: The Story of a Long Journey through First, Second, and Third Generation NS3/4A Peptidomimetic Inhibitors. What Did We Learn?
Martino SD, Petri GL, De Rosa M.
J Med Chem (2024) 67 : 885 -921
PubMed 38179950 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 7.82 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL231813 TELAPREVIR 4.0 1 7.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL231813 TELAPREVIR EC50 = 15.0 nM 7.82