Assay Detail
Binding
CHEMBL5539860
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Inhibition of Hepatitis C virus genotype 3a NS4B
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hepatitis C: The Story of a Long Journey through First, Second, and Third Generation NS3/4A Peptidomimetic Inhibitors. What Did We Learn?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.65 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5583648 | — | — | 1 | 9.33 |
| CHEMBL5568614 | — | — | 1 | 9.15 |
| CHEMBL258734 | DANOPREVIR | 3.0 | 1 | 8.46 |
| CHEMBL3952146 | — | — | 1 | 8.35 |
| CHEMBL3786672 | — | — | 1 | 8.24 |
| CHEMBL5570439 | — | — | 1 | 6.37 |
| CHEMBL4297647 | FURAPREVIR | 3.0 | 1 | 6.22 |
| CHEMBL3545363 | GLECAPREVIR | 4.0 | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5583648 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL5568614 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL258734 | DANOPREVIR | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3952146 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3786672 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5570439 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4297647 | FURAPREVIR | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3545363 | GLECAPREVIR | IC50 | = | 7900.0 | nM | 5.10 |